Nano Medical Hydroxyapatite
Naturally occurring calcium phosphate compound
Indicated by Health Canada to reduce cavities
Gold standard oral health ingredient in Japan
MECHANISM OF ACTION
The main substance of our teeth is hydroxyapatite (97 % of enamel and 70 % of dentin), a calcium phosphate compound. This ingredient is safe and highly biocompatible. Nano medical hydroxyapatite (<mHAP>) particles penetrate below the surface of the enamel, providing replacement calcium and phosphate ions to areas from which minerals have dissolved, thereby remineralizing the demineralized enamel and restoring its integrity and translucent gloss.
Remineralizes and repairs tooth surface
• Causes remineralization comparable to a fluoride toothpaste and inhibits caries development, thus suggesting that a nano medical hydroxyapatite toothpaste can be an effective alternative to fluoride toothpastes.1
• Remineralizes subsurface demineralized areas of tooth enamel.2
• Remineralizes tooth enamel more effectively than saliva and just as effectively as fluoride compounds.
Note : fluoride promotes remineralization by saliva, where as nano medical hydroxyapatite itself
remineralizes the teeth.3
• Fills and repairs minute surface defects on tooth enamel, restoring enamel to its original smoothness.4
• Adheres to and helps remove bacteria and biofilm, thereby protecting against tooth decay.5
• Removes white spots and incipient caries and restores enamel almost to its original form.6
• Protects against biofilm attachment and stains by reducing the crevices that harbor them.7
Antimicrobial properties
• Absorbs periodontal and opportunistic pathogens such as p. gingivalis and candida, helping reduce the risk of oral soft tissue infection.8
• Shows superior bacterial absorption compared to other forms of hydroxyapatite.9
• Shows strong selectivity for cariogenic streptococcus mutans.10
Tooth sensitivity
Medical Hydroxyapatite nanoparticles occlude and offer a protective coating beyond comparison over exposed dentinal tubules, providing quick and effective relief from refractory tooth hypersensitivity.
Coats and fills exposed dentin and dentinal tubules protecting against dentinal hypersensitivity.11
History of medical hydroxyapatite toothpastes
1970:
First synthetic form of hydroxyapatite created by NASA to help restore teeth and bone loss by astronauts following gravity-free environment missions.
1978:
Sangi Co., Ltd. acquires the patent from NASA and conceives the idea of an enamel-restorative toothpaste using the same substance as the tooth structure (hydroxyapatite).
1980:
Sangi launches the world’s first enamel-restorative toothpaste in Japan.
1985:
Studies from Tokyo Medical and Dental University (1 year / 1,026 children) and Asahi University (3 years / 181 children)
Results:
• Nano medical hydroxyapatite significantly lowered the incidence of new caries in previously and newly erupted teeth.
• In the 3-year study, the reduction was as high as 36 % to 56 %.
1993:
The Japanese government approves Sangi's proprietary medical hydroxyapatite as an active anti-caries agent.
2003:
Sangi increases the enamel-restorative capabilities of medical hydroxyapatite by reducing its nanoparticles from 100 to 50 nanometers (1 nanometer = 1 millionth of a millimeter), making it more effective at penetrating below the surface of the enamel.
2013:
• 100 million medical hydroxyapatite toothpastes sold by Sangi over the last 35 years.
• Nano medical hydroxyapatite is now the gold standard in Japan to fight cavities.
2015:
X-PUR Remin is granted the Health Canada indication of a fluoride free toothpaste that helps reduce caries.
References
- AMAECHI et al, Remineralization of Early Caries by a Nano-Hydroxyapatite Dentifrice, The Journal of Clinical Dentistry, 22(5), 139-143, 2011. [download]
- AMAECHI et al, Remineralization of Early Caries by a Nano-Hydroxyapatite Dentifrice, The Journal of Clinical Dentistry, 22(5), 139-143, 2011. [download]
- KANI et al, The Effect of Apatite-containing Dentifrices on Artificial Caries Lesions, The Journal of Dental Health 38, 364-366, 1988. [download]
- AMAECHI et al, Remineralization of Early Caries by a Nano-Hydroxyapatite Dentifrice, The Journal of Clinical Dentistry, 22(5), 139-143, 2011. [download]
- NISHIMURA et al, Demineralized Enamel Surface Microstructure after Brushing Using Toothpaste Containing Medical Hydroxyapatite under FE-SEM Observation, The Journal of Japanese Stomatological Society, 48(3), 199-210, 1999. [download]
- ARAKAWA et al, Reduction of Oral Mutans streptococci by Small-Crystals, 82nd General Session & Exhibition of the IADR, March 10-13, 2004. [download]
- ARAKAWA et al, Reduction of Oral Mutans Streptococci by Small Crystal Hydroxyapatite, The Journal of Dental Research, Vol. 83, 2036, Honolulu Abstracts, 2004. [download]
- AMAECHI et al, Remineralization of Early Caries by a Nano-Hydroxyapatite Dentifrice, The Journal of Clinical Dentistry, 22(5), 139-143, 2011. [download]
- ARAKAWA et al, Reduction of Oral Mutans Streptococci by Small Crystal Hydroxyapatite, Journal of Dental Research Vol. 81, A200-1478, San Diego Abstracts, 2002. [download]
- ARAKAWA et al, Adsorption Effect of Hydroxyapatite to Oral Streptococci, Journal of Dental Research, Vol. 83, 2036, Honolulu Abstracts, 2004. [download]
- KONDO et al, Study of Streptococcus Mutans Adherence to Hydroxyapatite, The Journal of Dental Health, Vol. 49, 614-615, 1999. [Article in Japanese]
- ARAKAWA et al, Reduction of Oral Mutans Streptococci by Small Crystal Hydroxyapatite, The Journal of Dental Research, Vol. 83, 2036, Honolulu Abstracts, 2004. [download]
- OHTA et al, Occlusion of Dentinal Tubules by Nano-Hydroxyapatite, The Journal of Dental Research, Vol 86, Special Issue A (New Orleans Abstract), 2007. [download]
- GUO et al, Effect of Hydroxyapatite Toothpaste on Vital Tooth Color, The Journal of Dental Research, Vol. 81, 1964, San Diego Abstracts, 2002. [download]